Immunobiology: The Immune System in Health and Disease

Janeway, Travers, Walport, Shlomchik

Fifth Edition

Part I. An Introduction to Immunobiology and Innate Immunity
 
1. Basic Concepts in Immunology
The components of the immune system
Principles of innate and adaptive immunity.
The recognition and effector mechanisms of adaptive immunity.
Summary to Chapter 1.
 
2. Innate Immunity
The front line of host defense.
The complement system and innate immunity.
Receptors of the innate immune system.
Induced innate responses to infection.
Summary to Chapter 2.
Part II. The Recognition of Antigen
 
3. Antigen Recognition by B-cell and T-cell Receptors
The structure of a typical antibody molecule.
The interaction of the antibody molecule with specific antigen.
Antigen recognition by T cells.
Summary to Chapter 3.
 
4. The Generation of Lymphocyte Antigen Receptors
The generation of diversity in immunoglobulins.
T-cell receptor gene rearrangement.
Structural variation in immunoglobulin constant regions.
Summary to Chapter 4.
 
5. Antigen Presentation to T Lymphocytes
The generation of T-cell receptor ligands.
The major histocompatibility complex and its functions.
Summary to Chapter 5.
Part III. The Development of Mature Lymphocyte Receptor Repertoires
 
6. Signaling Through Immune System Receptors
General principles of transmembrane signaling.
Antigen receptor structure and signaling pathways.
Other signaling pathways that contribute to lymphocyte behavior.
Summary to Chapter 6.
 
7. The Development and Survival of Lymphocytes
Generation of lymphocytes in bone marrow and thymus.
The rearrangement of antigen-receptor gene segments controls lymphocyte development.
Interaction with self antigens selects some lymphocytes for survival but eliminates others.
Survival and maturation of lymphocytes in peripheral lymphoid tissues.
Summary to Chapter 7.
Part IV. The Adaptive Immune Response
 
8. T Cell-Mediated Immunity
The production of armed effector T cells.
General properties of armed effector T cells.
T cell-mediated cytotoxicity.
Macrophage activation by armed CD4 TH1 cells.
Summary to Chapter 8.
 
9. The Humoral Immune Response
B-cell activation by armed helper T cells.
The distribution and functions of immunoglobulin isotypes.
The destruction of antibody-coated pathogens via Fc receptors.
Summary to Chapter 9.
 
10. Adaptive Immunity to Infection
Infectious agents and how they cause disease.
The course of the adaptive response to infection.
The mucosal immune system.
Immunological memory.
Summary to Chapter 10.
Part V. The Immune System in Health and Disease
 
11. Failures of Host Defense Mechanisms
Pathogens have evolved various means of evading or subverting normal host defenses.
Inherited immunodeficiency diseases.
Acquired immune deficiency syndrome.
Summary to Chapter 11.
 
12. Allergy and Hypersensitivity
The production of IgE.
Effector mechanisms in allergic reactions.
Hypersensitivity diseases.
Summary to Chapter 12.
 
13. Autoimmunity and Transplantation
Autoimmune responses are directed against self antigens.
Responses to alloantigens and transplant rejection.
Self-tolerance and its loss.
Summary to Chapter 13.
 
14. Manipulation of the Immune Response
Extrinsic regulation of unwanted immune responses.
Using the immune response to attack tumors.
Manipulating the immune response to fight infection.
Summary to Chapter 14.

 

Afterword. Evolution of the Immune System: Past, Present, and Future, by Charles A. Janeway, Jr.
Evolution of the innate immune system.
Evolution of the adaptive immune response.
The importance of immunological memory in fixing adaptive immunity in the genome.
Future directions of research in immunobiology.
Summary of the Afterword.
Appendix I. Immunologists' Toolbox
Immunization.
The detection, measurement, and characterization of antibodies and their use as research and diagnostic tools.
Isolation of lymphocytes.
Characterization of lymphocyte specificity, frequency, and function.
Detection of immunity in vivo.
Manipulation of the immune system.
Appendix II. CD Antigens.
Appendix III. Cytokines and Their Receptors.
Appendix IV. Chemokines and Their Receptors.
Appendix V. Immunological Constants.
Biographies
Glossary
 
References
 

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